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Update your Knowledge with MKSAP 18 Q&A

MKSAP 18MKSAP has been trusted by internists since 1967 as the best resource for updating knowledge. MKSAP 18, available in Complete, Digital, and Print packages, consists of 11 comprehensive text chapters with related multiple-choice questions. You'll find 1,200 completely new questions to help you identify learning gaps, stay current, and gain the knowledge you need to provide the best possible patient care. MKSAP 18's original and high-quality questions evolve out of case studies and patient scenarios based on the latest evidence.

For more information on MKSAP 18, or to order your copy, visit


A 24-year-old woman is admitted to the hospital with a right lower lobe pulmonary embolism. Her mother experienced a deep venous thrombosis 25 years ago. Weight-based intravenous heparin is initiated.

On physical examination, temperature and blood pressure are normal, pulse rate is 120/min, and respiration rate is 19/min. Oxygen saturation is 91% breathing ambient air. The examination is otherwise unremarkable.

Despite appropriately increasing doses of heparin, her activated partial thromboplastin time remains in the normal range.

Which of the following is the most likely diagnosis?

A: Antiphospholipid antibody syndrome
B: Antithrombin deficiency
C: Factor V Leiden
D: Protein C deficiency

Answer and Critique

Back to the July 2020 issue of ACP Global