Cardiac Amyloidosis

Amyloidosis is a pathologic and clinical condition resulting from the accumulation of misfolded proteins in tissues. Extracellular deposition of amyloid fibrils in the myocardium leads to cardiac amyloidosis, which is often overlooked as a cause of restrictive cardiomyopathy. Cardiac amyloidosis was previously believed to have a poor prognosis, but recent advances in diagnosis and treatment have emphasized the importance of early recognition and changed management of this important and often underrecognized clinical condition. This review provides an overview of cardiac amyloidosis and summarizes current screening, diagnosis, evaluation, and treatment options.

Use this article to:

  • What is the presentation of cardiac amyloidosis?
  • Do you have any patients with cardiac amyloidosis? How was it diagnosed?
  • Review the complications of untreated cardiac amyloidosis.
  • Review the available therapeutic strategies for treating cardiac amyloidosis.
  • Test your knowledge by completing the quiz that accompanies the article and then review the correct answers.

Annals of Internal Medicine is the premier internal medicine academic journal published by the American College of Physicians (ACP). It is one of the most widely cited and influential specialty medical journals in the world.

Back to the April 2023 issue of ACP IMpact