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In type 2 diabetes, weekly semaglutide reduced HbA1c and increased weight loss more than weekly exenatide ER

Source Citation Ahmann AJ, Capehorn M, Charpentier G, et al. Efficacy and safety of once-weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3): a 56-week, open-label, randomized clinical trial. Diabetes Care. 2018;41:258-66. 29246950

Intensive weight management in primary care improved weight loss and remission of type 2 diabetes

Source Citation Lean ME, Leslie WS, Barnes AC, et al. Primary care–led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet. 2017. [Epub ahead of print]. 29221645

Review: Newer second-line drugs for diabetes are not more cost-effective than sulfonylureas

Source Citation CADTH Therapeutic Reviews. New drugs for type 2 diabetes: second-line therapy–science report. Ottawa, ON: Canadian Agency for Drugs and Technologies in Health; Sep 2017.

In type 2 diabetes with CVD and kidney disease, empagliflozin reduced mortality and hospitalization

Source Citation Wanner C, Lachin JM, Inzucchi SE, et al; EMPA-REG OUTCOME Investigators. Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease. Circulation. 2018;137:119-29. 28904068

Review: In diabetes, intensive and standard glycemic control do not differ for end-stage kidney disease or death

Source Citation Ruospo M, Saglimbene VM, Palmer SC, et al. Glucose targets for preventing diabetic kidney disease and its progression. Cochrane Database Syst Rev. 2017;6:CD010137. 28594069

Self-monitoring of blood glucose did not improve HbA1c or QoL at 1 year in non–insulin-treated type 2 diabetes

Source Citation Young LA, Buse JB, Weaver MA, et al; Monitor Trial Group. Glucose self-monitoring in non-insulin-treated patients with type 2 diabetes in primary care settings: a randomized trial. JAMA Intern Med. 2017;177:920-9. 28600913

In type 1 diabetes, education with either insulin pumps or daily injections did not differ for HbA1c at 2 y

Source Citation REPOSE study group, Heller S, Amiel S, et al. Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ. 2017;356:j1285. 28360027

Review: Dapagliflozin increases, and empagliflozin reduces, adverse renal events in type 2 diabetes

Source Citation Tang H, Li D, Zhang J, et al. Sodium–glucose cotransporter 2 inhibitors and risk of adverse renal outcomes among type 2 diabetes patients: a network and cumulative meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2017 Feb 27 [Epub ahead of print]. 28240446

Exenatide did not reduce major cardiovascular outcomes in type 2 diabetes

Source Citation Holman RR, Bethel MA, Mentz RJ, et al; EXSCEL Study Group. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2017;377:1228-39. 28910237

Liraglutide reduced a composite renal outcome at a median 4 y in patients with type 2 diabetes and high CV risk

Source Citation Mann JFE, Ørsted DD, Brown-Frandsen K, et al; LEADER Steering Committee and Investigators. Liraglutide and renal outcomes in type 2 diabetes. N Engl J Med. 2017;377:839-48. 28854085