Annals for Educators - 6 September 2016

In primary biliary cholangitis, adding bezafibrate to ursodeoxycholic acid increased complete biochemical response

Source Citation Corpechot C, Chazouillères O, Rousseau A, et al. A placebo-controlled trial of bezafibrate in primary biliary cholangitis. N Engl J Med. 2018;378:2171-81. 29874528

After surgery for stage II or III colorectal cancer, more vs less frequent follow-up did not differ for 5-year mortality

Source Citation Wille-Jørgensen P, Syk I, Smedh K, et al; COLOFOL Study Group. Effect of more vs less frequent follow-up testing on overall and colorectal cancer-specific mortality in patients with stage II or III colorectal cancer: the COLOFOL randomized clinical trial. JAMA. 2018;319:2095-103. 29800179

In IBS with constipation, plecanatide reduced abdominal pain and increased bowel movements at 12 wk

Source Citation Brenner DM, Fogel R, Dorn SD, et al. Efficacy, safety, and tolerability of plecanatide in patients with irritable bowel syndrome with constipation: results of two phase 3 randomized clinical trials. Am J Gastroenterol. 2018;113:735-45. 29545635

In Barrett esophagus, high- vs low-dose esomeprazole improved clinical outcomes; aspirin vs no aspirin did not

Source Citation Jankowski JA, de Caestecker J, Love SB, et al. Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial. Lancet. 2018;392:400-8. 30057104

Fecal transplant by oral capsule was noninferior to delivery by colonoscopy for C difficile recurrence

Source Citation Kao D, Roach B, Silva M, et al. Effect of oral capsule- vs colonoscopy-delivered fecal microbiota transplantation on recurrent Clostridium difficile infection: a randomized clinical trial. JAMA. 2017;318:1985-93. 29183074

Review: In adult inpatients with mild or moderate acute pancreatitis, early feeding may reduce length of stay

Source Citation Vaughn VM, Shuster D, Rogers MAM, et al. Early versus delayed feeding in patients with acute pancreatitis: a systematic review. Ann Intern Med. 2017;166:883-92. 28505667

In nonvalvular AF, DOAC-related risk for GI bleeding was lower with apixaban than dabigatran or rivaroxaban

Source Citation Abraham NS, Noseworthy PA, Yao X, Sangaralingham LR, Shah ND. Gastrointestinal safety of direct oral anticoagulants: a large population-based study. Gastroenterology. 2017;152:1014-22.e1 28043907

In high-risk patients with arthritis and previous upper GI bleeding, celecoxib vs naproxen reduced recurrent bleeding

Source Citation Chan FK, Ching JY, Tse YK, et al. Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. Lancet. 2017;389:2375-82. 28410791

Glasgow Blatchford score predicted intervention or death better than 4 other prediction models in upper GI bleeding

Source Citation Stanley AJ, Laine L, Dalton HR, et al; International Gastrointestinal Bleeding Consortium. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study. BMJ. 2017;356:i6432. 28053181