Monkeypox: Challenging Clinical Questions

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In May 2022, monkeypox emerged in nonendemic regions of a world weary from years of dealing with COVID-19. The first U.S. case was reported on 17 May 2022, and on 4 August 2022 the Centers for Disease Control and Prevention (CDC) declared monkeypox a public health emergency. As of 30 September 2022, CDC was tracking 71 408 cases in more than 100 countries (1). Thankfully, as we approach mid-October 2022, the monkeypox outbreak seems to be ebbing. Among the 12 countries with the highest cumulative cases reported, the United States, Canada, and European countries are experiencing clear declines in incidence.

However, the virus remains a concern. As of 11 October 2022, there were 26 778 cases and 2 monkeypox-related deaths in the United States (1, 2). Monkeypox will likely continue to occur in previously nonendemic areas, although not at the dramatic rate initially feared. Consequently, clinicians need information about the prevention and management of an infection most have never encountered before. On 11 October 2022, Annals of Internal Medicine and the American College of Physicians gathered a panel of experts to provide that information in a virtual forum.


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Many webinars published by the Annals of Internal Medicine ( offer CME credit and MOC points, earned by viewing the content and subsequently completing a multiple-choice quiz to demonstrate knowledge. Note that CME and MOC availability typically expires 3 years after article publication, but quizzes remain available to allow learners to test their knowledge.