MKSAP 18 "Quiz Me!" Question

NEW! Test your medical knowledge each month with questions from The Medical Knowledge Self-Assessment Program® (MKSAP).

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MKSAP 18 Q & A

A 26-year-old woman is interested in genetic testing for BRCA1 and BRCA2 gene mutations based on her family history. Her mother was diagnosed with triple-negative breast cancer at age 53 years and died at age 55 years. Her maternal aunt was diagnosed with ovarian cancer at age 48 years and is still alive but is not interested in genetic testing. Her maternal and paternal relatives are of Ashkenazi Jewish descent. The patient is premenopausal and takes no medications.

On physical examination, vital signs are normal. Breast and gynecologic examination findings are normal.

Which of the following is the most appropriate management?

A: Recommend a direct-to-consumer genetic test
B: Recommend against genetic testing
C: Recommend genetic testing for the three BRCA1 and BRCA2 mutations most common in patients of Ashkenazi Jewish ethnicity
D: Refer to a genetic counselor

Answer and Critique

Back to the May 2021 issue of ACP IMpact