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Treatments of Primary Basal Cell Carcinoma of the Skin: A Systematic Review and Network Meta-analysis

Most interventions for basal cell carcinoma (BCC) have not been compared in head-to-head randomized trials. The purpose of this systematic review was to evaluate the comparative effectiveness and safety of treatments of primary BCC in adults.

Conclusion: Surgical treatments and external-beam radiation have low recurrence rates for the treatment of low-risk BCC, but substantial uncertainty exists about their comparative effectiveness versus other treatments. Gaps remain regarding high-risk BCC subtypes and important outcomes, including costs.

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Many articles published in the Annals of Internal Medicine ( offer CME credit and MOC points, earned by reading the articles and subsequently completing a multiple-choice quiz to demonstrate knowledge. Note that CME and MOC availability typically expires 3 years after article publication, but quizzes remain available to allow learners to test their knowledge.



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