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Folic Acid and Pregnancy | ACP We're sorry, but something went wrong

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Folic Acid

Why is folic acid important?

If women have enough folic acid in their bodies before pregnancy, this vitamin can decrease the risk for birth defects of the brain or spine. The U.S. Public Health Service recommends that all women who could possibly become pregnant get 400 micrograms (or 0.4 mg) of folic acid every day. There are many supplements that contain folic acid, making it easy to get the recommended levels each day.

This simple precaution prevents up to 70 percent of some types of serious birth defects. However, women need folic acid before they become pregnant, so it's important to have your levels checked if you are thinking about becoming pregnant.

Frequently Asked Questions about Folic Acid:

These FAQs will help educate you on the importance of consuming 400 micrograms of folic acid every day, which can help reduce the risk of spina bifida by 50 to 70 percent.

1. What is Folic Acid and What are Good Sources of this Vitamin?

Folic acid is a B-vitamin. The recommended amount to prevent spina bifida and other neural tube defects is 400 micrograms (0.4 milligrams) of synthetic folic acid daily.

Convenient ways to make sure that you get enough folic acid:

2. What are Neural Tube Defects (NTDs)?

Between the 17th and 30th day after conception (or 4 to 6 weeks after the first day of a woman's last menstrual period), the neural tube forms in the embryo (developing baby) and then closes. The neural tube later becomes the baby's spinal cord, spine, brain, and skull. A Neural Tube Defect (NTD) occurs when the neural tube fails to close properly, leaving the developing brain or spinal cord exposed to the amniotic fluid. The two most common neural tube defects are anencephaly and spina bifida.

Folic acid in a vitamin supplement, when taken one month before conception and throughout the first trimester, has been proven to reduce the risk for an NTD-affected pregnancy by 50 to 70 percent. Folic acid is necessary for proper cell growth and development of the embryo. Although it is not known exactly how folic acid works to prevent NTDs, its role in tissue formation is essential. Folic acid is required for the production of DNA, which is necessary for the rapid cell growth needed to make fetal tissues and organs early in pregnancy. That is why it is important for a woman to have enough folic acid in her body both before and during pregnancy.

3. What are Spina Bifida and Anencephaly?

Spina Bifida and Anencephaly are birth defects that occur in the first four weeks of pregnancy, before most women know that they are pregnant. Because about half of all pregnancies are unplanned, women of childbearing age should include 400 micrograms of folic acid in their diet every day.

Anencephaly is a fatal condition in which the upper end of the neural tube fails to close. In these cases, the brain either never completely develops or is totally absent. Pregnancies affected by Anencephaly often result in miscarriages. Infants who are born alive die very soon after birth.

4. What Are the Risk Factors Associated with NTD?

Anyone who becomes pregnant can have an NTD-affected pregnancy. There are no known causes for NTD but there are certain risk factors to consider:

5. Can Women Get Too Much Folic Acid?

Folic acid has no known toxic level. If you were to eat a bowl of fully fortified cereal (400 micrograms), take 400 micrograms (0.4 milligram) folic acid supplement, and eat fortified foods and foods rich in folate, women of reproductive age would not have a problem with too much folic acid. Even in very high amounts folic acid is non-toxic. Nevertheless, it is recommended that women consume no more than 1,000 micrograms of synthetic folic acid a day. Large amounts of folic acid may hide the ability to quickly diagnose pernicious anemia, a rare vitamin B-12 deficiency. This condition primarily affects the elderly population and, in some cases, can lead to neurological damage. Today, doctors can use a simple definitive test to check for a B-12 deficiency.

6. Are Women Getting Enough Folic Acid?

Even though there are several ways to get 400 micrograms (0.4 milligram) of folic acid every day, two thirds of women in the United States do not consume adequate amounts of folic acid.

7. What Are the Costs Associated with NTDs?

The average total lifetime cost to society for each infant born with spina bifida is approximately $532,000 per child. This estimate is only an average, and for many children the total cost may be well above $1,000,000.

8. What Are Other Health Benefits of Taking Folic Acid?

High levels of the amino acid homocysteine are independently associated with an increased risk of heart disease and stroke. It has been shown that taking folic acid lowers homocysteine levels in both men and women, but it is not yet known whether folic acid supplementation also lowers the risk of heart disease and stroke.

There are some indications that folic acid use may also reduce the risk for other birth defects, such as cleft lip and palate and certain congenital heart defects. Folic acid may also play a role in protecting against some forms of cancer and heart disease. More research is needed to understand the impact of folic acid in preventing those diseases and other birth defects.

Annals of Internal Medicine Patient Summaries

Search for folic acid in ACP's Annals of Internal Medicine Patient Summaries. Annals of Internal Medicine is the leading peer-reviewed internal medicine clinical journal.

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