• Treat to BP < 140/90 mm Hg or BP < 130/80 mm Hg in patients with diabetes or chronic kidney disease. ACP recommends BP < 135/80 mm Hg for diabetics (see Annals of Internal Medicine, April 2003)
• Diuretics, particularly thiazides, are generally the first choice for therapy unless contraindicated or there is a compelling indication to use another drug (see below).
• Majority of patients will require two medications to reach goal.

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