From The American College of Physicians: The First 75 Years. Annals of Internal Medicine, 1 June 1990. 112:872-878.
| 1915 | Incorporation. American Congress of Internal Medicine, 8 January. INCORPORATION. AMERICAN COLLEGE OF PHYSICIANS. 11 May. Certificate of Incorporation, State of Delaware, 19 May. First Meeting, Fellows and officers elected; bylaws adopted, 25 June. |
| 1918 | Death of Heinrich Stern, founder. |
| 1922 | REORGANIZATION. BOARD OF REGENTS AND BOARD OF GOVERNORS. Annals of Clinical Medicine launched for the College by Williams & Wilkins. |
| 1925 | Alfred Stengel, President, and steps to academic leadership. |
| 1926 | Headquarters moved to Philadelphia. Edward R. Loveland, appointed Executive Secretary (1926-1959). The College and the American Congress on Internal Medicine merge. |
| 1927 | Annals of Internal Medicinefounded. Aldred Scott Warthin, Editor of the former journal, 1924-1927, is appointed Editor (1927-1931). |
| 1928 | Board of Regents reorganized. Charles Martin, President (1928-29). Life membership endowments. |
| 1929 | John Phillips Memorial Award established. First awarded in 1932. |
| 1931 | Maurice J. Pincoffs, appointed Editor, Annals of Internal Medicine (1931-1960). |
| 1934 | Research Scholarships established (precursor to Teaching and Research Scholars). American Board of Medical Specialties established. |
| 1935 | AMERICAN BOARD OF INTERNAL MEDICINE founded, with ACP support. Headquarters purchased, 4200 Pine Street, Philadelphia. |
| 1936 | First postgraduate courses sponsored. |
| 1939 | Conference Committee on Graduate Medical Training. |
| 1940 | ACP 25th anniversary. James D. Bruce, President; Roger I. Lee, President-Elect. |
| 1941 | Regional Meetings formalized. |
| 1951 | JOINT COMMISSION ON ACCREDITATION OF HOSPITALS founded with ACP support. |
| 1953 | Residency Review Committee-Internal Medicine founded with ACP support. |
| 1955 | Commission on Professional and Hospital Activities established. |
| 1956 | American Society of Internal Medicine (ASIM) founded. |
| 1960 | Edward C. Rosenow, Jr. (1960-1977) appointed as the College's first physician chief-executive. J. Russell Elkinton appointed Editor, Annals of Internal Medicine (1960-1971). |
| 1961 | ACP first represented on AMA Advisory Committees in Medical Education. |
| 1965 | ACP 50th anniversary. A. Carl Ernstene, President; Irving S. Wright, President-Elect. Council of Medical Specialty Societies established. |
| 1967 | MEDICAL KNOWLEDGE SELF ASSESSMENT PROGRAM (MKSAP) started. |
| 1969 | Associates reclassed to permanent Members. Physicians in training admitted as Associates. |
| 1970 | Membership at 17,000 |
| 1971 | Edward J. Huth appointed Editor, Annals of Internal Medicine (1971-1990). Proposed amalgamation of ACP and ASIM fails. MKSAP, first Japanese edition. |
| 1972 | Medical Practice Committee. |
| 1973 | ABIM recertification and in-training examinations. |
| 1974 | TORONTO CONFERENCE OF REGENTS AND GOVERNORS. ACP New Mexico and Illinois Chapters incorporated. ABIM Conference on Primary Care. Federated Council for Internal Medicine founded. |
| 1976 | Medical Necessity Project started. |
| 1977 | Robert H. Moser appointed Executive Vice President (1977-1986). ACP Council of Subspecialty Societies established. |
| 1978 | TASK FORCE ON STRUCTURE AND FUNCTION. HEALTH AND PUBLIC POLICY Department started. Forum on Medicine first published. Society for Research and Education in Primary Care Internal Medicine founded with ACP support. Institute of Medicine Statement: A Manpower Policy for Primary Health Care. |
| 1979 | ACP Council of Medical Societies started. First report on studies of the National Study of Internal Medicine Manpower, Annals of Internal Medicine (1979-1985). Private Initiative in Quality Assurance. |
| 1980 | AMA. Future Directions for Medical Education. ACP Conference on the Changing Needs of Nursing Home Care. |
| 1981 | CLINICAL EFFICACY ASSESSMENT PROJECT started. Accreditation Council for Medical Education. GMENAC Report. ACP Observer replaces Forum on Medicine. |
| 1982 | HEALTH AND PUBLIC POLICY Committee appointed and Washington Office opened. |
| 1984 | Headquarters relocation study. ACP Ethics Manual. ACP-Upjohn: Healthscope. |
| 1985 | Guide to Adult Immunization.Medical Informatics Subcommittee formed. |
| 1986 | John R. Ball appointed Executive Vice President (1986- ). Clinical Privileges Project started. |
| 1987 | Society for General Internal Medicine (renamed from SREPCIM). |
| 1989 | Move to new ACP headquarters, Sixth Street at Race, Philadelphia. Collaboration with Lifetime Medical Television started. ACP Ethics Manual, 2nd edition. |
| 1990 | ACP 75th anniversary. Norton J. Greenberger, President; Nicholas E. Davies, President-Elect. MKSAP, first Spanish edition. Robert H. Fletcher and Suzanne W. Fletcher appointed Editors, Annals of Internal Medicine. Membership exceeds 68,000. |