1999 Resident Poster Competition
Osama Mitri M.D.
Univ. of Missouri--Kansas City
Vascular Compliance and Risk of Cardiovascular Disease
Background: vascular compliance is probably reduced long time before the clinical evidence of cardiovascular disease, and it is considered by some a predictor of cardiovascular disease.
Objective: to detect factors that might affect vascular compliance in young healthy subjects, and to detect whether family history of cardiovascular disease affects vascular compliance at young age.
Results: 143 subjects ages 18-33 were enrolled, small artery elasticity was significantly reduced in females (P<0.0001), with increased age (P= 0.0011), lower BMI (P=0.0003), and a higher heart rate (P<0.0001), large artery elasticity was significantly reduced in females (P=0.004), and with lower BMI (P=0.015). There was no significant difference in vascular compliance in relation to family history of cardiovascular disease, but there was a trend towards decreased small artery elasticity in subjects with parental history of hyperlipidemia (P=0.062).
Conclusion: Gender and BMI significantly affected small and large artery elasticity, age and heart rate significantly affected only small artery elasticity. There was a trend towards a reduced small artery elasticity in the presence of parental history of hyperlipidemia.
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Alan D Forker, MD MACP
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Patrick Mills
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